Every stroke begins with a sudden interruption of blood flow in the brain. But what happens afterward—why neurons continue to ...

The goal of my research program is to define the molecular mechanisms that regulate how glial cells take on harmful or beneficial cell states in health and disease. I am particularly interested in how ...

When the brain is injured in some way, a wide range of biochemical changes are triggered that can affect crucial brain cells known as astrocytes. They are a type of glial cell, and brain injuries ...

A new platform for screening astrocyte reactivity helps researchers uncover potential therapeutic interventions to treat neurodegenerative conditions. Led by postdoctoral researcher Benjamin Clayton, ...

In neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS, excessive H2O2 from reactive astrocytes triggers a vicious cycle of oxidative stress, protein aggregation, and neuronal loss.

How do astrocytes react to Alzheimer’s disease pathology? It’s complicated, according to the largest single-nuclei RNA-Seq study of these cells published thus far. Scientists led by Sudeshna Das at ...

By growing cells in a lab, Steven Sloan, new group leader at the Netherlands Institute for Neuroscience, has uncovered a new function in the brain’s support cells (astrocytes). “These findings give us ...

Astrocytes are notoriously two-faced—calmly coddling neurons one minute, then ruthlessly consuming their synapses the next. Why these dramatic mood swings? Blame the EphA4 receptor, according to a ...

UT Southwestern Medical Center scientists have identified a protein that appears to act as a master control switch for reactive gliosis, a prominent feature of many neurodegenerative diseases that is ...

Much of the brain is made up of a constellation of star-shaped cells called astrocytes, which play vital roles in immunity, neuron maintenance and many other functions. In Alzheimer’s disease, some ...